The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! NIH is still unsure whether fluvoxamine should be used to treat COVID PDF Fluvoxamine - The backstory Comparison with molnupiravir. Thanks to the volumes of data and information provided by pharmaceutical companies and regulators, as well as large numbers of trials from independently funded research groups around the world, I now trust that theyre safe for the vast majority of adults. At the end of May this year, Siliciano emailed the other advisors to say that Kirsch had gone off the deep end and he was cutting ties. Some countries dont have fluvoxamine so this is the alternative. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. As Kirsch has gone deeper into the anti-vaccine scene, many professional associates have increasingly distanced themselves from him. Di scl ai mer: T he vi ews expressed i n t hi s art i cl e are my own personal opi ni on based on my 1, 000+ hour st udy of cut t i ng edge . Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). In September, Kirsch emailed Morris asking him to estimate the maximum number of deaths caused by vaccines. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. A very short op-ed arguing for using fluvoxamine against COVID. . Were having trouble saving your preferences. It is very safe: There is no evidence fluvoxamine is harmful and led to a worse outcome. He applied the drug to a large COVID outbreak at Golden Gate Fields just days after the Lenze trial was published. In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. We dont want to feed the anti-vaccine trolls, so we actively suppress clear scientific data. Compulsive fiddling with your mask? Fluvoxamine public data repository: The fluvoxamine public repository has all the documents related to fluvoxamine for COVID, including the RCT, RWE, observational studies and a link to the 1 hour lecture on serotonin and fluvoxamine. More recently, hes adopted extremist positions on covid vaccines, which he alleges are toxic. He has claimed that one in 1,000 people who have received mRNA vaccines have died as a result, and even claimed the vaccines kill more people than they save at an FDA public forum, which was first reported by the Daily Beast. People who report not tolerating the drug are typically prescribed too high a dose. Fluvoxamine, COVID, pandemic, . 1. Over the next few years, millions of unvaccinated people are going to get covid; its vital to try to mitigate their suffering, as well as lessen pressure on the health care system. And FrameMaker is still a niche product. Personal life. (PDF) 9th International Congress on Psychopharmacology - academia.edu Its a cycle that feeds mistrust and boosts the profiles of influencers who present themselves in opposition to official authorities. I have never heard of a case it didn't work. But a panel of key opinion leaders from the NIH, CDC . That trial has now been completed, and the researchers are analyzing their data. So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? Although there is evidence that fluvoxamine can prevent clinical worsening and the need for hospitalizations in outpatients with early covid-19, I have seen no good evidence that fluvoxamine is useful as a substitute for the vaccines, co-investigator Angela Reiersen wrote to me. Who knows, Morris replied. All the researchers are convinced the drug works. And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? See the repository above. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. I am not aware of a single case where taking the made things worse, e.g., person was doing fine BEFORE the drug and symptoms worsened after taking the drug. If you cant get a prescription for COVID, then perhaps you have OCD? Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 1.15K 'This Has Cost Millions of Lives': Steve Kirsch on Suppression of Repurposed Drugs and a Spike in Deaths 5 Months After Vaccine Rollout American Thought Leaders AMERICAN THOUGHT LEADERS JAN JEKIELEK Show more Loading comments. Twenty-four years ago, . We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Indeed, some of the most prominent people spreading misinformation about ivermectin and vaccines today began by promoting hydroxychloroquineincluding by claiming to debunk Boulwares data analysis. All the medical journals refused to publish the meeting notes (rejected by 6 journals). Fluvoxamine is also an So it was both obvious and convincing the difference between the groups to the workers and the track management. Vaccine waitlist Dr. B collected data from millions. Their willingness to lie did. Things took a final and dramatic turn once Kirsch started claiming the government was covering up vaccine deaths. Please read and agree to the disclaimer before watching this video.. Steve Kirsch On COVID Early Treatment and CensorshipSteve Kirsch is an entrepreneur and . It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for, because they were rejected by 10 journals. There were no studies reported out so far where fluvoxamine made things worse or neutral. ). I couldn't agree more. It's hard to ignore this lecture in explaining why the drug is so effective. We could have saved a lot of lives. Expect similar things to happen when Eiger applies for an EUA for interferon lambda, a drug with a 89% efficacy in phase 3 trials. Both drugs have compelling data that is hard to explain if the drug doesn't work. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). Why not fluvoxamine? Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. 1991-1992 to 7.1% in 2001-2002. How can the FDA say a drug which meets the gold standard of evidence has insufficient evidence? I have all of these on hand and I load up on vitamin D3 every day. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. 90,000 people will die in the next 3 weeks alone if we continue to ignore this drug that has caused no harm. . Ivermectin and fluvoxamine have been confirmed in Phase 3 trials. We should be making decisions now based on the evidence on the table today. 707. 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. vocus This suggests that a 50mg BID loading dose for day one, followed by 50mg QD dose for the following 13 days should also be quite effective. Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. O, Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19 | Blood Advances | American Society of Hematology, Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Fluvoxamine for COVID-19 Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Drug Repurposing Research Leads to Potentially Game-Changing Treatment to Prevent Clinical Deterioration in Outpatients With COVID, The Covid-19 Early Treatment Fund was launched to provide funding for research in order to, Steve Kirschs answer to What is the current treatment for Covid-19? We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. Dosage there is 30mg once a day. They left their recommendation of fluvoxamine at NEUTRAL. Its not about the science. reach out to us at Its whether Merck can make a killing that matters. Steve Kirsch is an inventor of the optimal mouse, a Silicon Valley millionaire, and an MIT alum (Class of '80). Fluvoxamine has a 40 year safety track record. Silence from the medical community. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. (PDF) Kaplan Textbook of Psychiatry JL copy - Academia.edu - Share research He may not be a good scientist, but hes smart, says WVUs Feinberg. But the whole process has gone too slowly for Kirsch. Doctors who have used fluvoxamine in the US and other countries swear by it. Server IP address resolved: Yes Http response code: 200 Response time: 0.27 sec. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Is fluvoxamine helpful for patients with the coronavirus? Is it - Quora Fluvoxamine has at least a 30% hospitalization and death benefit. On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. saying that the per-protocol analysis was arbitrary and other excuses. Fluvoxamine has a 40 year safety track record. Steve Kirsch. It was approved by the FDA in 1994 and has been used in millions of patients worldwide. Proven in clinical use all over the world. When I asked him why so many experts in the field disagreed with him, he alleged there were effortseither malicious or negligentto suppress evidence of cheap, effective covid treatments. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. It was so bad you couldnt even see the babys body through all the blood, Kirsch said. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. So far, doctors have failed to share his sense of urgency. That receptor also helps regulate the body's . CETF Founder Steve Kirsch discusses why we can't wait for a COVID-19 vaccine, the importance of researching existing drugs now, and our work to raise funds for outpatient trials to identify effective . CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. (The fund borrows its nonprofit status from the 501(c)(3) Rockefeller Philanthropy Advisors, which managed its money until it quit, according to the Daily Beast; neither organization is related to the Rockefeller Foundation, which supports Technology Review's reporting on covid.). The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. My experience is very typical. He retired at the largest pension in federal history. In a recent post, discussing claims Kirsch made during a three-minute comment at an FDA public forum, Morris wrote: In spite of many pages of writing and claims of over a dozen independent analyses verifying their results, their evidence falls far short of substantiating these dramatic conclusions, including a claim that vaccines have caused >250K excess deaths in the USA.. The data we have today with just 2 clinical trials (RCT and confirmatory RWE) is compelling. Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19). Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. I agreed to do it partially because I respect Bob [Siliciano] so much, and partially because I thought the concept was excellent, said former board member Doug Richman, a prominent HIV drug researcher at the University of California San Diego and former member of the funds scientific advisory board. Download Citation | On Mar 1, 2023, Gne Seda Albayrak and others published A Cross-Sectional Study on the Personality Traits of Episodic and Chronic Migraine Patients | Find, read and cite all . People who report not tolerating the drug are typically prescribed too high a dose. Steve Kirsch: $25,000 to Anyone that Proves Fluvoxamine - TrialSiteNews Physicians who use the drug for COVID now swear by it. It cant be more clear than this. So you can address your OCD and if you get COVID, youll can up the dose. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. Hes also publicly railed against what he claims is a campaign against drugs like fluvoxamine and ivermectin. Steve Kirsch reported that doctors commonly say (of fluvoxamine), "This is the most powerful drug in my arsenal. At that dose, no side effects were reported for his patients (I know of only one person who had mild nausea at that dose) and everyone reversed out their symptoms in an average of 3 days. Delta vocus Early treatment with existing drugs is the fastest, most effective, and lowest. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. In 2016, it was the 135th most-prescribed medication in the United States, with more than 4 million prescriptions. Several former members told me he began relentlessly pressuring them to promote the drug in media stories, often during exhausting, circuitous conversations. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. How can we get fluvoxamine? customer-service@technologyreview.com with a list of newsletters youd like to receive. While he declined a phone interview, Boulware was recently the subject of a Mother Jones article about the harassment hes received for his research on hydroxychloroquine and ivermectin. The sooner you start, the better the outcomes. Nov 12: Steve Kirsch gives talk on CETF to HarvardBusiness School hosted by Dr. Seftel Nov 13:Mass COVID outbreak at GGF is now publiclyknown Nov 16: Seftel, the track physician at GGF, startsFLV . I took it myself at that dosage and noticed zero side effects. Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. If you cant lay off the java, then try fluoxetine (Prozac). He was recently featured on 60 Minutes which highlighted his . This document is a collection of evidence that highlights the glaring errors in our pandemic response. Compulsive hand washing? In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! Compulsive hand washing? Doctors who have used fluvoxamine in the US and other countries swear by it. Hes spending his own money to do what he thinks is right. Why the FDA should grant an EUA for fluvoxamine immediately, a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients. Fluvoxamine: Finding a possible early treatment for COVID-19 in a 40 He is frequently brash and interruptive, peppering dire warnings about vaccines with veiled aspersions toward Anthony Fauci and vague references to influential people who agree with him in private but cannot speak publicly. Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. . 95% confidence effect size is 75% or more. Always be self aware when using fluvoxamine. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. Added to FLCCC protocols and Fareed-Tyson protocol among others. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. In September, he resigned as CEO and gave up his board seat. It was tested in. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. Doctors have no excuse for not prescribing. Steve Kirsch (@stkirsch) / Twitter - Twitter. It's what's happening Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Mr. Steve Kirsch - A philanthropist and former Silicon Valley tech executive. They were giving covid patients the antidepressant fluvoxamine as soon as possible after diagnosis, based on anecdotes about the drug limiting the runaway immune response that causes many severe symptoms. Fluvoxamine Data Unveiled as Promising Early Treatment in Patients with just like ivermectin). It never was. Steve is a Silicon Valley entrepreneur and philanthropist who founded the COVID-19 Early Treatment Fund (CETF) at the beginning of the pandemic. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. To date, the #1 drug with the most evidence to make a significant difference, without any doubt, is fluvoxamine. And, according to three members of CETF's scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for . Get your prescription in advance of getting COVID. FDA official fluvoxamine rejection. Compulsive fiddling with your mask? Steve Kirsch and Dr. Robert Malone, MIT COVID-19 Postgame - Substack In the studies and the anecdotes I am aware of, everyone reversed symptoms within days of getting the drug. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Timing is everything with respect to outcomes. Worst case, if we ignore all additional evidence so the average is a 60% pass rate. Food/drugs to avoid while on fluvoxamine. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. Its all about NIH saying it is OK. . The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. If you were drowning and we had no known standard of care to save your life and someone had a life preserver which worked 160 times in a row, should we throw them the life preserver or let them drown because we aren't absolutely sure the life preserver's benefit > risk (since just because it worked 160 times in a row and there is a 99.99% chance the effect didn't happen by chance, we could have just gotten lucky). It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. Note that some of these articles are inaccurate. There may be a depression of libido while on drug, but since the drug is taken on acute basis, this is only temporary and it reverses once the drug is stopped. Reason is the hospital gets release from liability if they follow NIH guidelines. Boulware disputes that, and says that although Kirschs funding was important, his statements about drugs and vaccines have proven problematic. just like ivermectin). Everyone says "we need more data" to show fluvoxamine works for COVID. Long haul. . He has made millions from these projects, even if they have not turned him into a household name. If you cant get a prescription for COVID, then perhaps you have OCD? Some are views most scientists think are wrong. Steve Kirsch Executive Director at COVID-19 Early Treatment Fund (2020-present) Author has 176 answers and 1.7M answer views Updated 1 y Both. Once the Phase 2 result came out, it should have been embraced by doctors. We have a bounty of vaccines and more on the way, but drugs that treat the disease are vital too if we want to keep people alive and bring the pandemic under control. Some speaker, off camera, went on a . Antidepressant fluvoxamine could keep mild COVID-19 from worsening Tech Tycoon Steve Kirsch Dangled a COVID Cure and Then Went Full Anti He immediately tweeted an offer to give anyone $1 million if they could win a debate with him about vaccine deaths. He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. Everyone is stunned, but nobody is surprised. But fear of trying something new prevents any doctor from giving this drug a try.